As the title suggests… there’s a lot of conflicting info out there. There’s a lot of talk of “clearing receptor sites” and there’s two camps:
Receptors upregulate: from my understanding, when you have more androgens binding to receptors the body makes more receptors available.
Receptors downregulate: once a car (androgen) is in the parking spot (site) it’s not available any longer and you’re gonna need more and more AAS to illicit response.
The receptor site is a door, the binding acts a key that allows signals to be sent to the cell to do its job.
Personally… I don’t know what’s right. I’m looking for any scholarly articles that show inclination to one or
If downregulation is in fact what happens, why don’t people need more and more testosterone for effective HRT?
If I’m way off, or there’s a definitive answer out there, lemme know!